ARA-290 (cibinetide) is a non-hematopoietic derivative of erythropoietin, researched for its activity on the innate repair receptor rather than the classic erythropoietin receptor. It is studied for potential benefits in neuropathic pain modulation, peripheral nerve tissue protection, and anti-inflammatory signaling, with particular research interest in small-fiber neuropathy models.

Chemical Structure: ARA-290 is a short synthetic peptide derived from the tertiary structure of the erythropoietin molecule’s helix-B surface peptide (HBSP) region.